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The mathematical theories in
   evolutionary genetics  indicate that
   When animals become extinct,
     'genetic meltdown'  may be the last stage
 
When a particular species' population
      drops below a certain level :
          their genes accumulate bad mutations
Their DNA sequence suffers many deletions
      Big chunks of genome go missing
                    that even affect functional genes
 
The species may lose such functions as
    -  the sense of smell
    -  or  the ability to attract the opposite sex
That's because,  in very small populations,
     natural selection becomes very inefficient
DNA clues to why
        woolly mammoth died out
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